May 24, 2005   Joseph McWherter, M.D., Medical Editor / Jeff Morris, Editor
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Table Of Contents

Featured Articles
Nutrigenomics and the Blood Type Diet
Technologies for Aesthetic Medicine
LipoSonix and UltraShape: New Non-Invasive Alternatives to Liposuction

Ask The Experts
Hormone Modulation and Replacement - Tom Bader R.Ph
Botox® and Fillers - Dr. Mark Baily, M.D.
Practice Management - Featured Expert Dr. Alan Mintz
Industry Profile
The Old de Grey Man, He Is What He Chose To Be
Guest Viewpoint
New Frontiers of Neuroendocrinology: Has America Gone Crazy?
Industry News
Heart Drugs May Prevent Cancer
Need Help Cutting Back on Alcohol? Try Kudzu
Drug Meant For Symptoms Treats a Disease
Scientists Create First Customized Stem Cells
Conference News
Vegas Conference Curriculum Receives Accolades
Achievement in Research & Clinical Excellence Awards Announced: Presentation to Take Place at Palm Beach Anti-Aging Conference

Featured Articles

Nutrigenomics and the Blood Type Diet
Jeff Morris
Rather than keep you hanging on the false promise that we're going to present anything new or astonishing here about a dietary breakthrough, we'll get this out of the way right up front: we started working on this article determined to find some evidence to support the idea that The Blood Type Diet is a truly remarkable example of how genetic research can be used to better patients' lives, and that it is backed up with verifiable studies.

It didn't happen.

Let's start, however, by talking not about the Blood Type Diet, but about the science of which it is allegedly a part: Nutrigenomics. Nutritional genomics, or "nutrigenomics," is the study of how different foods can interact with particular genes to increase the risk of diseases such as Type 2 diabetes, obesity, heart disease and some cancers. It is fascinating and promising research, largely begun in 2003 with the establishment of the National Center of Excellence in Nutritional Genomics at the University of California, Davis, and the Children's Hospital Oakland Research Institute (CHORI), supported by a five-year, $6.5 million grant from the National Center on Minority Health and Health Disparities, a division of the National Institutes of Health. FULL ARTICLE


Technologies for Aesthetic Medicine
LipoSonix and UltraShape: New Non-Invasive Alternatives to Liposuction

Jeff Morris
New aesthetic medicine technologies that are currently in the development stage promise to offer non-invasive alternatives to liposuction. Two companies are competing to bring devices to market that, while not identical, utilize similar ultrasonic principles to break up fat cells. Neither is likely to be on the market prior to 2006, but both offer the prospect of a lower-cost, less painful outpatient treatment regimen than liposuction.

LipoSonix, Inc., based in Bothell, WA, was founded in 1999 by The Innovation Factory, an Atlanta technology company "incubator" focused on developing life science technologies into breakthrough products. The patented LipoSonix device is called SonoSculpt. LipoSonix chief executive Jens Quistgaard, who was formerly chief product and strategy officer at handheld ultrasound maker SonoSite, moved the 3-person start-up to the Seattle area, one of the leading regions for developers of ultrasound medical devices, noting, "It doesn't make any sense to do this type of company in Atlanta; the technology is ultrasound-based so you have to do it where there are ultrasound people." Quistgaard says the SonoSculpt procedure will take about an hour in a plastic surgeon's office, with results that can be seen in about four to six weeks. Because the SonoSculpt does not involve surgery, Quistgaard said the device could help grow the market for weight loss procedures. "If you have something that is safe and non-invasive, people that don't consider themselves as candidates for surgery would certainly consider this," he said. FULL ARTICLE



Ask The Experts

Hormone Modulation and Replacement - Tom Bader R.Ph
HORMONE MODULATION AND REPLACEMENT
Tom Bader, R.Ph.
Owner and Chief Pharmacist
College Pharmacy
www.collegepharmacy.com


Botox® and Fillers - Dr. Mark Baily, M.D.
BOTOX® AND FILLERS
Dr. Mark Baily, B.Sc., M.D.
Certified Botox® Instructor
Cosmetic & Laser Training Institute
www.cltinstitute.com


Practice Management - Featured Expert Dr. Alan Mintz
BUSINESS AND PRACTICE DEVELOPMENT FOR AGE MANAGEMENT MEDICINE
Dr. Alan Mintz
Dr. Alan Mintz
Cenegenics Cenegenics Medical Institute
cenegenics.com

View All Experts



Industry Profile

The Old de Grey Man, He Is What He Chose To Be
Jeff Morris

Aubrey de Grey is driving people crazy, and he likes it that way. Unfortunately, I'm one of those people.

The 42-year-old computer scientist, self-taught biologist, and chairman of The Methuselah Foundation, presents a challenge as the subject of a profile. It's not that information about him is hard to come by, or that he's squirreled himself away in some obscure corner of the English countryside refusing to talk to anyone, or that you have to go through a dozen PR people and be put on a waiting list to get through to him. On the contrary, I found him to be easy to get hold of, remarkably forthcoming, and the subject of enough written material -- much of it by his own hand -- that there isn't a heck of a lot about him still to be discovered. Which is precisely the problem: The main difficulty is in trying to find some way to write about him that hasn't already been done.

I spoke with Dr. de Grey, who received his BA, MA and PhD degrees from the University of Cambridge, at what must have been around 9 pm Cambridge time. As is apparently commonplace for him, I didn't really need to ask him a question; he simply launched into his answer. FULL ARTICLE



Guest Viewpoint

New Frontiers of Neuroendocrinology: Has America Gone Crazy?
Ron Shane, Ph.D.
Countless artists, biologists, psychologists, psychiatrists and philosophers have lucidly explicated that this culture is becoming mentally pathological. A bevy of mental morbidities are now actually epidemic in this population. General anxiety syndrome is as pervasive as having an SUV. Dysthymia is the current omnipresent state of the American psyche. This culture's fascination with technology may be the etiological basis of neurophysiological morbidities. "All is not well," as stated by Shakespeare in the play Hamlet, and this now is the mood of this society. The sagacious toolmaker is producing objects of emotional devastation.

Social psychologists suggest that man is extremely adaptive. However, there is a limit to this species' proclivity to adapt. Neuroscientists have empirically demonstrated that the human brain is magnificently hardwired, where trillions of axons have a very precise connection to specific dendrite. In other words, the human brain is not some arbitrary blank slate which is as protean as the HO2 molecular. Conversely, these highly differentiated neuronal tissues have evolved to evoke myriad species-specific responses. This seemingly adaptive organism does have a limit to its plasticity before maladaptive responses and neurophysiological dysregulation become virulently flagrant. FULL ARTICLE


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Industry News

Heart Drugs May Prevent Cancer
Michael Smith
United Press International
Monday, May 16, 2005

ORLANDO, Fla., May 16, 2005 (United Press International via COMTEX) -- New research suggests certain cholesterol-lowering drugs people take to prevent heart disease also might ward off at least five types of cancer, but physicians and drugmakers are not ready to make prescribing recommendations based on the early data.

The studies on the statin drugs, presented at the annual meeting of the American Society for Clinical Oncology, as well as at a cancer conference in Chicago on Monday, are encouraging, researchers said. Statins are sold under the brand names Lescol, Lipitor, Mevacor, Pravachol, and Zocor.

"Right now, if you need to be prescribed a drug for cholesterol lowering, many studies suggest you would be better off choosing a statin for its cancer-preventive effect," said Vikas Khurana, an assistant professor of medicine at Louisiana State University Health Sciences Center in Shreveport. Khurana was one of the researchers who presented data in Orlando. FULL ARTICLE


Need Help Cutting Back on Alcohol? Try Kudzu
Alison McCook

Monday, May 16, 2005

NEW YORK (Reuters Health) - Heavy drinkers who tried the herbal extract kudzu for one week downed fewer drinks than people who received an inactive placebo treatment, according to new study findings released Monday.

Study author Dr. Scott E. Lukas of McLean Hospital and Harvard Medical Center in Massachusetts explained that during the experiment, people drank their first beer right away, but were less likely to want more beer if they had taken kudzu the previous week.

"This means that the first beer must have satisfied their initial desire for alcohol," Lukas suggested.

He said that kudzu may also help deliver blood to the brain, making people more satisfied with less alcohol. "We can see this in the data because people took more sips in order to finish each beer, but the sips were much smaller," Lukas said.

"The net result was that a binge drinker - someone who drinks 4-5 drinks at one sitting - was reduced to just a few beers," he told Reuters Health.
FULL ARTICLE


Drug Meant For Symptoms Treats a Disease
In startling twist, experimental leukemia drug may be breakthrough

The Associated Press

Updated: 9:26 a.m. ET May 16, 2005

ORLANDO, Fla. - Doctors were just hoping to treat symptoms when they gave people with a deadly blood disorder a drug to reduce the need for transfusions.

To their astonishment, signs of the disease itself disappeared in nearly half of them.

Specialists said the experimental drug, Revlimid, now looks like a breakthrough and the first effective treatment for many people with myelodysplastic syndrome, or MDS, which is even more common than leukemia.

"It may be, if not eradicating the disease, putting it into what I would call deep remission," said Dr. David Johnson, a cancer specialist at Vanderbilt-Ingram Cancer Center who is familiar with but had no role in the research.

Revlimid "is not yet on the market but almost certainly will be" because of these findings, he said.

MDS refers to a group of disorders caused by the bone marrow not making enough healthy, mature blood cells. About 15,000 to 20,000 new cases are diagnosed each year in the United States, and as many as 50,000 Americans have it now. They usually suffer anemia and fatigue and need blood transfusions about every eight weeks to stay alive.

"It's a serious problem, it tends to occur in older people, and it's fatal for most," said Dr. Herman Kattlove, a blood disorder specialist at the American Cancer Society. FULL ARTICLE


Scientists Create First Customized Stem Cells
The Associated Press
Friday, May 20, 2005

WASHINGTON -- South Korean scientists have dramatically sped up the creation of human embryonic stem cells (search), growing 11 new batches that for the first time were a genetic match for injured or sick patients.

It is a major advancement in the quest to grow patients' own replacement tissue to treat diseases.

The same scientists last year were the first to clone a human embryo. Now they have improved, by more than tenfold, their efficiency at culling these master cells, thus making pursuit of therapeutic cloning more practical.

"I didn't think they would be at this stage for decades, let alone within a year," said Dr. Gerald Schatten of the University of Pittsburgh. He acted as an adviser to the Korean lab in analyzing its data, which was being published Friday in the journal Science.

"This paper will be of major impact," said stem-cell researcher Dr. Rudolph Jaenisch of the Whitehead Institute for Biomedical Research (search) in Cambridge, Mass. FULL ARTICLE



Conference News

Vegas Conference Curriculum Receives Accolades
The Spring 2005 Integrative Medicine for Anti-Aging Conference was held May 12-15th at the Las Vegas Hilton, and based upon attendee comments and evaluations, the conference curriculum dominated the event. Conference attendees -- an all-time high of over 90% physicians -- attended four days of lectures focused on Diseases of Aging, Aesthetics, Hormone Replacement and Integrative Medicine. Attendee Benito Gallardo, M.D., said, "this conference provided really good information and has the topics that are applicable to our growing anti-aging practice." Martha Stark, M.D., a faculty member at Harvard Medical School, stated, "the level of instruction was very high and sophisticated. I am very impressed with how generous and eager the speakers were to offer everything from theory to clinical applications, so that it all made sense.... I got the 'why's' and the 'how to's'."

There were some pretty clear attendee favorites. Dr. Mark Baily's lectures on the use of Botox and Fillers were undoubtedly the most attended events of the conference. The desire for increased practice revenue outside of managed care by the addition of office-based aesthetic treatments such as Botox and Soft Tissue Fillers, has driven attendees to this course repeatedly over the past several years. Dr. Baily, who conducts hands-on physician training in his Brompton, Ontario, Canada clinic, provided a clear outline of aesthetic applications including a live demonstration of injection techniques. FULL ARTICLE


Achievement in Research & Clinical Excellence Awards Announced: Presentation to Take Place at Palm Beach Anti-Aging Conference
In just about every area of medicine, practitioners whose distinguished accomplishments as clinicians reflect honor on the discipline, and researchers whose scientific curiosity and diligence result in new breakthroughs that benefit humanity, are recognized for their contributions.

Now, a definitive new awards program is being established to acknowledge outstanding work of physicians and scientists in the growing field of anti-aging/age management medicine. The Peer-Review Planning Committee of the Integrative Medicine for Anti-Aging conference will accept nominations for the first Achievement in Research and Clinical Excellence Awards.

In announcing the award program, Joseph McWherter, M.D., FACOG, FACS, chairman of the Committee, noted, "Promotion of healthy aging is an imperative that is becoming more critical as an ever-increasing proportion of the worldwide population reaches the later stages of life. With the healthcare systems of all nations facing this unprecedented resource challenge, amelioration of the diseases of aging is a vital strategy for maintaining full functionality."

McWherter continued, "Few medical fields have assembled as impressive a body of significant progress within a relatively brief timeframe as age management. It is appropriate that the clinicians who are influencing lifestyle changes and the researchers taking the knowledge to new levels be acknowledged for their contributions."

The nomination process is set to begin immediately, and the winners will be honored at a presentation at the Integrative Medicine for Anti-Aging Conference at the Palm Beach Convention Center in West Palm Beach, FL, in October, 2005.


For the nomination criteria and to make your own selections of potential award recipients, go to http://images.antiagingconference.com/files/1103/aagateway/awards.asp


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